Anti-Human CD3 SAFIRE Purified

Grouped product items
Size Price Qty
100 μg
$150.00
500 μg
$260.00

Additional UCHT1 Formats

Cat.No. Format Starting From
05131-20 Purified $ 75.00
05131-25 SAFIRE Purified $ 150.00
05131-87 APC-Cyanine7 $ 115.00
05131-50 FITC $ 40.00
05131-77 PE-Cyanine7 $ 115.00
05131-40 BG Violet 450 $ 85.00
05131-80 APC $ 65.00
05131-70 PerCP-Cyanine5.5 $ 135.00
05131-30 Biotin $ 65.00
05131-60 PE $ 55.00
05131-65 PE-Cyanine5 $ 120.00
05131-45 BG Violet 500 $ 110.00
Catalog Number : 05131-25

description

The UCHT1 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.

Unlike HIT3a, another specific antibody of CD3, the UCHT1 antibody can stain both the surface and intracellular CD3ε. The immobilized UCHT1 can cross-link with the TCR complex, enhancing cellular activation and proliferation.

Additional Information

Clone:
UCHT1
Format:
SAFIRE Purified
Applications:
FC, FA, IHC, IF, IP, WB
Reactivity:
Human
Isotype:
Mouse IgG1, kappa
Research Interest: Adaptive Immunity
Cell Type: Th17 cells, NK and NKT Cells, T Cells, T Regulatory Cells
Application: FC, FA, IHC, IF, IP, WB
Clone: UCHT1
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.

McMichael, A. J. (1987). Leucocyte typing III. Oxford University Press, Oxford. Norton AJ, Isaacson PG (1985)

Beverley, P. C., & Callard, R. E. (1981). Distinctive functional characteristics of human T lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody. European journal of immunology11(4), 329-334.

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