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Anti-Human CD289 (TLR9) PE



Catalog Number : 31011-60

Description

The 72-1665 monoclonal antibody specifically reacts with CD289, also known as human toll-like receptor 9 (TLR9). CD289 is involved in the activation of innate immunity, in acquired immune responses, and autoimmune diseases. It is involved in the immune system’s response to unmethylated CpG dinucleotide sequences such as those found in bacterial, viral, or synthetic DNA. CD289 assists in pathogen recognition and is expressed by subtypes of dendritic cells and B cells.

Additional Information

Clone:
72-1665
Format:
PE
Applications:
FC
Reactivity:
Human
Isotype:
Rat IgG2a, kappa
Research Interest: Innate Immunity
Cell Type: Monocytes and Macrophages, Dendritic Cells
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Latz, E., Schoenemeyer, A., Visintin, A., Fitzgerald, K. A., Monks, B. G., Knetter, C. F., ... & Golenbock, D. T. (2004). TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nature immunology5(2), 190-198.

Leifer, C. A., Kennedy, M. N., Mazzoni, A., Lee, C., Kruhlak, M. J., & Segal, D. M. (2004). TLR9 is localized in the endoplasmic reticulum prior to stimulation.The Journal of Immunology173(2), 1179-1183.

József, L., Khreiss, T., El Kebir, D., & Filep, J. G. (2006). Activation of TLR-9 induces IL-8 secretion through peroxynitrite signaling in human neutrophils. The Journal of immunology176(2), 1195-1202.


Availability: In stock

Size Price Qty
25ug
$170.00
100 ug
$390.00
Additional 72-1665 Formats
Cat.No. Format Starting From
31011-60PE $ 170.00