Anti-Human CD28 PE
Additional CD28.2 Formats
| Cat.No. | Format | Starting From |
|---|---|---|
| 10311-77 | PE-Cyanine7 | $ 115.00 |
| 10311-20 | Purified | $ 75.00 |
| 10311-25 | SAFIRE Purified | $ 130.00 |
| 10311-50 | FITC | $ 70.00 |
| 10311-80 | APC | $ 105.00 |
| 10311-60 | PE | $ 80.00 |
| 10311-70 | PerCP-Cyanine5.5 | $ 135.00 |
description
The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes. CD28 is a ligand for B7-1 (CD80) and B7-2 (CD86), a co-stimulator of T lymphocytes, and enhances the interaction between T and B lymphocytes. It has been reported that the T lymphocytes stimulation to produce IL-2 depends on the monoclonal antibody involved, which suggests that the CD28 molecule presents some subregions with distinct functions. The CD28.2 antibody induces Ca2+ influx in Jurkat T lymphocytes. Other studies have shown that CD28 is involved in the signal transduction.
Additional Information
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Clone:
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CD28.2
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Format:
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PE
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Applications:
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FC
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Reactivity:
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Human
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Isotype:
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Mouse IgG1, kappa
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| Research Interest: | Adaptive Immunity |
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| Cell Type: | T Cells |
| Application: | FC |
| Clone: | CD28.2 |
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Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York Nunès, J., Klasen, S., Ragueneau, M., Pavon, C., Couez, D., Mawas, C., ... & Olive, D. (1993). CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: analysis of early and late activation events.International immunology, 5(3), 311-315. Karlsson, I., Malleret, B., Brochard, P., Delache, B., Calvo, J., Le Grand, R., & Vaslin, B. (2007). FoxP3+ CD25+ CD8+ T-cell induction during primary simian immunodeficiency virus infection in cynomolgus macaques correlates with low CD4+ T-cell activation and high viral load. Journal of virology, 81(24), 13444-13455. |