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Anti-Human CD278 (ICOS) PE-Cyanine7



Catalog Number : 30811-77

Description

The ISA-3 monoclonal antibody specifically reacts with human CD278 or Inducible COStimulatory molecule (ICOS), a 47-60 kDA homodimeric glycoprotein also known as H4, AILIM, and CRP-1. It is expressed on activated T cells and a group of thymocytes and is involved in the proliferation, activation, and cytokine production of T cells. When plate-bound, the ISA-3 antibody induces the production of IL-4,5,10 in T cells.

Additional Information

Clone:
ISA-3
Format:
PE-Cyanine7
Applications:
FC
Reactivity:
Human
Isotype:
Mouse IgG1, kappa
Research Interest: Adaptive Immunity
Cell Type: T Cells
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., & Kroczek, R. A. (1999). ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature402, 21-24.

Quiroga, M. F., Pasquinelli, V., Martínez, G. J., Jurado, J. O., Zorrilla, L. C., Musella, R. M., ... & García, V. E. (2006). Inducible costimulator: a modulator of IFN-γ production in human tuberculosis. The Journal of Immunology176(10), 5965-5974.

Buonfiglio, D., Bragardo, M., Redoglia, V., Vaschetto, R., Bottarel, F., Bonissoni, S., ... & Dianzani, U. (2000). The T cell activation molecule H4 and the CD28‐like molecule ICOS are identical. European journal of immunology,30(12), 3463-3467.


Availability: In stock

Size Price Qty
25 tests
$120.00
100 tests
$310.00
Additional ISA-3 Formats
Cat.No. Format Starting From
30811-60PE $ 170.00
30811-77PE-Cyanine7 $ 120.00