Anti-Human CD274 (PD-L1, B7-H1) APC
Catalog Number : 26811-80
description
The MIH1 monoclonal antibody specifically reacts with human CD274, also known as B7-H1 or PD-L1, a glycoprotein of the B7 family of the immunoglobulin superfamily. CD274 is expressed on the B and T lymphocytes, natural killer cells, and dendritic cells. The receptor for the B7-H1 molecule is PD-1, which contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM), and is expressed on activated B and T cells. The interaction between CD274 and PD-1 seems to downregulate the T and B immune responses. The MIH1 antibody is reported to be a blocking antibody.
Additional Information
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Clone:
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MIH1
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Format:
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APC
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Applications:
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FC
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Reactivity:
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Human
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Isotype:
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Mouse IgG1, kappa
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| Research Interest: | Adaptive Immunity |
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| Cell Type: | B Cells, T Cells |
| Application: | FC |
| Clone: | MIH1 |
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Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Marzec, M., Zhang, Q., Goradia, A., Raghunath, P. N., Liu, X., Paessler, M., ... & Wasik, M. A. (2008). Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1). Proceedings of the National Academy of Sciences, 105(52), 20852-20857. Boes, M., & Meyer-Wentrup, F. (2015). TLR3 triggering regulates PD-L1 (CD274) expression in human neuroblastoma cells. Cancer letters, 361(1), 49-56. Wilcox, R. A., Feldman, A. L., Wada, D. A., Yang, Z. Z., Comfere, N. I., Dong, H., ... & Witzig, T. E. (2009). B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. Blood, 114(10), 2149-2158. |