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Anti-Human CD16 SAFIRE Purified



Catalog Number : 08211-25

Description

The CB15 monoclonal antibody specifically binds to human CD16, a low affinity Fc receptor. It is expressed on NK, neutrophils, macrophages, monocytes, and placental trophoblasts. CD16 is expressed in CD16a and CD16b forms. CD16a is a polyeptide anchored transmembrane protein and CD16b is a monomeric glycosylphosphatidylinositol (GPI)-anchored protein found in neutrophils. CD16 is reported to be involved in NK cell activation and signal transduction.

Additional Information

Clone:
CB16
Format:
SAFIRE Purified
Applications:
FC, FA
Reactivity:
Human
Isotype:
Mouse IgG1
Research Interest: Innate Immunity
Cell Type: Monocytes and Macrophages, NK and NKT Cells
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Wirthmueller, U., Kurosaki, T., Murakami, M. S., & Ravetch, J. V. (1992). Signal transduction by Fc gamma RIII (CD16) is mediated through the gamma chain. The Journal of experimental medicine175(5), 1381-1390.

Deaglio, S., Zubiaur, M., Gregorini, A., Bottarel, F., Ausiello, C. M., Dianzani, U., ... & Malavasi, F. (2002). Human CD38 and CD16 are functionally dependent and physically associated in natural killer cells. Blood99(7), 2490-2498.

Araya, N., Takahashi, K., Sato, T., Nakamura, T., Sawa, C., Hasegawa, D., ... & Yamano, Y. (2011). Fucoidan therapy decreases the proviral load in patients with human T-lymphotropic virus type-1-associated neurological disease.Antiviral therapy16(1), 89.


Availability: In stock

Size Price Qty
500 ug
$410.00
Additional CB16 Formats
Cat.No. Format Starting From
08211-50FITC $ 90.00
08211-25SAFIRE Purified $ 410.00
08211-80APC $ 120.00
08211-77PE-Cyanine7 $ 155.00