Anti-Human CD127 APC

Grouped product items
SizePrice Qty
25 tests
$150.00
100 tests
$340.00

Additional RDR5 Formats

Cat.No.FormatStarting From
19321-65PE-Cyanine5$ 140.00
19321-80APC$ 150.00
19321-60PE$ 134.00
Catalog Number : 19321-80

description

The RDR5 monoclonal antibody specifically reacts with human CD127, a 60-90 kDA type I transmembrane glycoprotein also known as the IL-7 receptor alpha chain. CD127 binds with CD132 (gamma c) to forms the IL-7 receptor that is expressed on mature T cells and immature B cells. Since CD127 expression is downregulated in Treg cells, it can be used as a marker for differentiating them from common T cells. The binding of the RDR5 antibody can be blocked by pre-incubating the cells with human IL-7.

Additional Information

Clone:
RDR5
Format:
APC
Applications:
FC
Reactivity:
Human
Isotype:
Mouse IgG1, kappa
Research Interest:Cytokines & Growth Factors
Cell Type:B Cells, T Cells, T Regulatory Cells
Application:FC
Clone:RDR5
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Corcoran, A. E., Smart, F. M., Cowling, R. J., Crompton, T., Owen, M. J., & Venkitaraman, A. R. (1996). The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis. The EMBO journal15(8), 1924.

Lim, H. W., & Kim, C. H. (2007). Loss of IL-7 receptor α on CD4+ T cells defines terminally differentiated B cell-helping effector T cells in a B cell-rich lymphoid tissue. The Journal of Immunology179(11), 7448-7456.

Goodwin, R. G., Friend, D., Ziegler, S. F., Jerzy, R., Falk, B. A., Gimpel, S., ... & Park, L. S. (1990). Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily.Cell60(6), 941-951.

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