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Anti-Human CD116 FITC



Catalog Number : 18211-50

Description

The 4H1 monoclonal antibody specifically bind to human CD116, a 70-85 kD alpha chain of the GM-CSF receptor. It forms the high affinity GM-CSF receptor with CD131 as the beta chain. CD116 is expressed on macrophages, monocytes, eosinophils, dendritic cells, fibroblasts, neutrophils, and some tumor cells.

Additional Information

Clone:
4H1
Format:
FITC
Applications:
FC
Reactivity:
Human
Isotype:
Mouse IgG1, kappa
Research Interest: Innate Immunity, Angiogenesis
Cell Type: Dendritic Cells, Monocytes and Macrophages
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Woodcock, J. M., McClure, B. J., Stomski, F. C., Elliott, M. J., Bagley, C. J., & Lopez, A. F. (1997). The human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor exists as a preformed receptor complex that can be activated by GM-CSF, interleukin-3, or interleukin-5. Blood90(8), 3005-3017.

Lopez, A. F., Vadas, M. A., Woodcock, J. M., Milton, S. E., Lewis, A., Elliott, M. J., ... & Park, L. S. (1991). Interleukin-5, interleukin-3, and granulocyte-macrophage colony-stimulating factor cross-compete for binding to cell surface receptors on human eosinophils. Journal of Biological Chemistry266(36), 24741-24747.

Guthridge, M. A., Barry, E. F., Felquer, F. A., McClure, B. J., Stomski, F. C., Ramshaw, H., & Lopez, A. F. (2004). The phosphoserine-585–dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-κB and induction of bcl-2. Blood103(3), 820-827.


Availability: In stock

Size Price Qty
25 tests
$90.00
100 tests
$200.00
Additional 4H1 Formats
Cat.No. Format Starting From
18211-50FITC $ 90.00
18211-60PE $ 120.00