Anti-Human B7-H4 SAFIRE Purified
Additional H74 Formats
| Cat.No. | Format | Starting From |
|---|---|---|
| 86611-25 | SAFIRE Purified | $ 595.00 |
Catalog Number : 86611-25
description
The H74 monoclonal antibody binds to human B7-H4, a newly discovered member of the B7 family involved with the negative regulation of T cell immunity. B7-H4 is a type I membrane glycoprotein also known as B7S1, B7X, and VCTN1. Its role in tumor progression may be to protect precancerous cells from the surveillance of the immune system. Further studies are being conducted to determine the exact B7-H4 ligand. It is reported that the H74 antibody binds to human B7-H4 transfected cells and not peripheral blood cells.
Additional Information
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Clone:
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H74
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Format:
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SAFIRE Purified
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Applications:
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FC
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Reactivity:
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Human
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Isotype:
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Mouse IgG1, kappa
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| Research Interest: | Adaptive Immunity |
|---|---|
| Application: | FC |
| Clone: | H74 |
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Preparation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Choi, I. H., Zhu, G., Sica, G. L., Strome, S. E., Cheville, J. C., Lau, J. S., ... & Chen, L. (2003). Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family. The Journal of Immunology,171(9), 4650-4654. Sica, G. L., Choi, I. H., Zhu, G., Tamada, K., Wang, S. D., Tamura, H., ... & Chen, L. (2003). B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity, 18(6), 849-861. Yao, Y., Wang, X., Jin, K., Zhu, J., Wang, Y., Xiong, S., ... & Zhou, L. (2008). B7-H4 is preferentially expressed in non-dividing brain tumor cells and in a subset of brain tumor stem-like cells. Journal of neuro-oncology, 89(2), 121-129. |