Anti-Human CD163 PE
Catalog Number : 15711-60
description
The GHI/61 antibody specifically reacts with human CD163, high affinity scavenger receptor for the hemoglobin-haptoglobin complex and a common marker for cells of the monocyte/macrophage lineage. It is reported to be involved in the regulation of cytokine production and functions as the innate immune sensor for gram-positive and gram-negative bacteria.
Additional Information
Clone:
|
GHI/61
|
Format:
|
PE
|
Applications:
|
FC
|
Reactivity:
|
Human
|
Isotype:
|
Mouse IgG1, kappa
|
Research Interest: | Innate Immunity |
---|---|
Cell Type: | Macrophage / Monocyte |
Application: | FC |
Clone: | GHI/61 |
Preparation:
|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
|
Formulation:
|
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
|
References:
|
Pulford, K., Micklem, K., McCarthy, S., Cordell, J., Jones, M., & Mason, D. Y. (1992). A monocyte/macrophage antigen recognized by the four antibodies GHI/61, Ber-MAC3, Ki-M8 and SM4. Immunology, 75(4), 588. Ritter, M., Buechler, C., Langmann, T., Orso, E., Klucken, J., & Schmitz, G. (1999). The scavenger receptor CD163: regulation, promoter structure and genomic organization. Pathobiology, 67(5-6), 257-261. Maniecki, M. B., Etzerodt, A., Moestrup, S. K., Møller, H. J., & Graversen, J. H. (2011). Comparative assessment of the recognition of domain-specific CD163 monoclonal antibodies in human monocytes explains wide discrepancy in reported levels of cellular surface CD163 expression. Immunobiology, 216(8), 882-890. |