Anti-Human CD163 PE-Cyanine7
Catalog Number : 15711-77
description
The GHI/61 antibody specifically reacts with human CD163, high affinity scavenger receptor for the hemoglobin-haptoglobin complex and a common marker for cells of the monocyte/macrophage lineage. It is reported to be involved in the regulation of cytokine production and functions as the innate immune sensor for gram-positive and gram-negative bacteria.
Additional Information
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Clone:
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GHI/61
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Format:
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PE-Cyanine7
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Applications:
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FC
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Reactivity:
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Human
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Isotype:
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Mouse IgG1, kappa
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| Research Interest: | Innate Immunity |
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| Cell Type: | Macrophage / Monocyte |
| Application: | FC |
| Clone: | GHI/61 |
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Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Pulford, K., Micklem, K., McCarthy, S., Cordell, J., Jones, M., & Mason, D. Y. (1992). A monocyte/macrophage antigen recognized by the four antibodies GHI/61, Ber-MAC3, Ki-M8 and SM4. Immunology, 75(4), 588. Ritter, M., Buechler, C., Langmann, T., Orso, E., Klucken, J., & Schmitz, G. (1999). The scavenger receptor CD163: regulation, promoter structure and genomic organization. Pathobiology, 67(5-6), 257-261. Maniecki, M. B., Etzerodt, A., Moestrup, S. K., Møller, H. J., & Graversen, J. H. (2011). Comparative assessment of the recognition of domain-specific CD163 monoclonal antibodies in human monocytes explains wide discrepancy in reported levels of cellular surface CD163 expression. Immunobiology, 216(8), 882-890. |