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Anti-Human CD107a (LAMP-1) PE



Catalog Number : 19111-60

Description

The H4A3 monoclonal antibody specifically reacts with human CD107a, a heavily glycosylated type I membrane glycoprotein. CD107a is also known as Lysosomal-associated membrane protein 1 (LAMP-1) and is widely expressed intracellular antigen. It can be found on the surface of PHA-activated lymphocytes, activated platelets, cytotoxic T cells, NK cells, macrophages, epithelial cells, endothelial cells, and some tumor lines. CD107a is a ligand for E-selectin and galaptin and is reported to be involved in cell adhesion and tumor metastasis.

Additional Information

Clone:
H4A3
Format:
PE
Applications:
FC
Reactivity:
Human
Isotype:
Mouse IgG1, kappa
Research Interest: Innate Immunity
Cell Type: T Cells, Monocytes and Macrophages, NK and NKT Cells
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Chen, J. W., Cha, Y. I. N. G., Yuksel, K. U., Gracy, R. W., & August, J. T. (1988). Isolation and sequencing of a cDNA clone encoding lysosomal membrane glycoprotein mouse LAMP-1. Sequence similarity to proteins bearing onco-differentiation antigens. Journal of Biological Chemistry263(18), 8754-8758.

Grützkau, A., Smorodchenko, A., Lippert, U., Kirchhof, L., Artuc, M., & Henz, B. M. (2004). LAMP‐1 and LAMP‐2, but not LAMP‐3, are reliable markers for activation‐induced secretion of human mast cells. Cytometry Part A61(1), 62-68.

Sarafian, V., Jadot, M., Foidart, J. M., Letesson, J. J., Van den Brule, F., Castronovo, V., ... & Coninck, W. D. (1998). Expression of Lamp‐1 and Lamp‐2 and their interactions with galectin‐3 in human tumor cells. International journal of cancer75(1), 105-111.


Availability: In stock

Size Price Qty
25 tests
$120.00
100 tests
$265.00
Additional H4A3 Formats
Cat.No. Format Starting From
19111-60PE $ 120.00
19111-20Purified $ 60.00
19111-50FITC $ 110.00
19111-80APC $ 150.00