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Animal-Free Recombinant Human TGF-β3 (E.coli derived)



Catalog Number : AF-100-36E

Description

The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-β3 is still unknown but its expression pattern suggests a role in the regulation of certain development processes. Recombinant human TGF-β3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond. Manufactured using all non-animal reagents.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Cow, Dog, Mouse, Pig, Rat
 
Biological Activity
The ED50 was determined by TGF-β3’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥2 x 10<
 
AA Sequence
ALDTNYCFR NLEENCCVR PLYIDFRQD LGWKWVHEP KGYYANFCS GPCPYLRSA DTTHSTVLG LYNTLNPEA SASPCCVPQ DLEPLTILY YVGRTPKVE QLSNMVVKS CKCS
Research Interest: Innate Immunity, Adaptive Immunity, Stem Cell Research, Apoptosis, Cancer, Angiogenesis, Inflammation, Proliferation and Cell Cycle
Protein Cross Reactivity: Cow, Dog, Mouse, Pig, Rat

Availability: In stock

Size Price Qty
10µg
$215.00
100µg
$1,716.00
500µg
$5,148.00
1mg
$8,580.00