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Animal-Free Recombinant Human NT-3



Catalog Number : AF-450-03

Description

NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6 kDa polypeptide monomers (240 total amino acid residues). Human and Mouse NT-3 sequences are identical. Manufactured using all non-animal reagents.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Chicken, Cow, Dog, Frog, Hamster, Mouse, Pig, Rat
 
Biological Activity
The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 20-50 ng/ml.
 
AA Sequence
MYAEHKSHR GEYSVCDSE SLWVTDKSS AIDIRGHQV TVLGEIKTG NSPVKQYFY ETRCKEARP VKNGCRGID DKHWNSQCK TSQTYVRAL TSENNKLVG WRWIRIDTS CVCALSRKI GRT
Research Interest: Stem Cell Research, Neurosciences
Cell Type: Neurons
Protein Cross Reactivity: Chicken, Cow, Dog, Frog, Hamster, Mouse, Pig, Rat

Availability: In stock

Size Price Qty
10µg
$215.00
100µg
$1,140.00
500µg
$3,420.00
1mg
$5,700.00