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Animal-Free Recombinant Human IL-21



Catalog Number : AF-200-21

Description

IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant human IL-21 is a 15.4 kDa protein consisting of 132 amino acid residues. Manufactured using all non-animal reagents.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Mouse
 
Biological Activity
Assay #1:Determined by its ability to proliferate activated B cells.

Assay #2:Determined by its ability to induce human CD40L-activated naïve B cells to undergo Ig isotype switching to IgG, using an IL-
 
AA Sequence
MQDRHMIRM RQLIDIVDQ LKNYVNDLV PEFLPAPED VETNCEWSA FSCFQKAQL KSANTGNNE RIINVSIKK LKRKPPSTN AGRRQKHRL TCPSCDSYE KKPPKEFLE RFKSLLQKM IHQHLSSRT HGSEDS
Research Interest: Adaptive Immunity, Stem Cell Research, Apoptosis, Immunology, Cancer
Cell Type: B Cells, T Cells
Protein Cross Reactivity: Mouse

Availability: In stock

Size Price Qty
10µg
$215.00
100µg
$1,140.00
500µg
$3,420.00
1mg
$5,700.00