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Animal-Free Recombinant Human IL-1Ra



Catalog Number : AF-200-01RA

Description

Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein. It inhibits the activity of IL-1α and IL-1β by competitively blocking binding to their type I and type II receptors. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL-1Ra may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Recombinant human IL-1Ra is a 17.2 kDa protein consisting of 153 amino acid residues. Manufactured using all non-animal reagents.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Frog, Mouse, Rat
 
Biological Activity
Determined by its ability to inhibit the IL-1α stimulation of murine D10S cell. The expected ED50 is 20-40 ng/ml in the presence of 50 pg/ml of IL-1α.
 
AA Sequence
MRPSGRKSS KMQAFRIWD VNQKTFYLR NNQLVAGYL QGPNVNLEE KIDVVPIEP HALFLGIHG GKMCLSCVK SGDETRLQL EAVNITDLS ENRKQDKRF AFIRSDSGP TTSFESAAC PGWFLCTAM EADQPVSLT NMPDEGVMV TKFYFQEDE
Research Interest: Innate Immunity, Neurosciences, Inflammation, Metabolic Regulation and Diabetes
Cell Type: Monocytes and Macrophages
Protein Cross Reactivity: Frog, Mouse, Rat

Availability: In stock

Size Price Qty
100µg
$215.00
250µg
$420.00
500µg
$720.00
1mg
$1,200.00