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Animal-Free Recombinant Human IL-13



Catalog Number : AF-200-13

Description

IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells.  Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites.  IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8.  IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE.  Blocking of IL-13 activity inhibits the pathophysiology of asthma.  Human and murine IL-13 is cross-species reactive.  Recombinant human IL-13 is a 12.6 kDa protein consisting of 115 amino acid residues. Manufactured using all non-animal reagents.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Mouse
 
Biological Activity
The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
 
AA Sequence
MSPGPVPPS TALRELIEE LVNITQNQK APLCNGSMV WSINLTAGM YCAALESLI NVSGCSAIE KTQRMLSGF CPHKVSAGQ FSSLHVRDT KIEVAQFVK DLLLHLKKL FREGRFN
Research Interest: Innate Immunity, Adaptive Immunity, Stem Cell Research, Immunology, Cancer, Inflammation
Cell Type: Monocytes and Macrophages, T Cells
Protein Cross Reactivity: Mouse

Availability: In stock

Size Price Qty
10µg
$215.00
100µg
$1,140.00
500µg
$3,420.00
1mg
$5,700.00