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Animal-Free Recombinant Human Flt3-Ligand



Catalog Number : AF-300-19

Description

Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand exerts no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Recombinant human Flt3-Ligand is a soluble 17.6 kDa protein consisting of 155 amino acid residues. Manufactured using all non-animal reagents.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Monkey, Mouse, Rat
 
Biological Activity
The ED50 was determined by the dose-dependent stimulation of the proliferation of human AML5 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
 
AA Sequence
TQDCSFQHS PISSDFAVK IRELSDYLL QDYPVTVAS NLQDEELCG GLWRLVLAQ RWMERLKTV AGSKMQGLL ERVNTEIHF VTKCAFQPP PSCLRFVQT NISRLLQET SEQLVALKP WITRQNFSR CLELQCQPD SSTLPPPWS PRPLEATAP TA
Research Interest: Stem Cell Research, Immunology, Cancer, Proliferation and Cell Cycle
Cell Type: Stem Cells
Protein Cross Reactivity: Monkey, Mouse, Rat

Availability: In stock

Size Price Qty
10µg
$215.00
100µg
$860.00
500µg
$2,580.00
1mg
$4,300.00