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Animal-Free Recombinant Human BAFF



Catalog Number : AF-310-13

Description

BAFF, a member of the TNF family of ligands, is expressed in T cells, macrophages, monocytes and dendritic cells. BAFF is involved in stimulation of B and T cell function, and is an important survival and maturation factor for peripheral B cells. BAFF signals through three different TNF receptors TACI, BCMA and BAFF-R. The human BAFF gene codes for a 285 amino acid type II transmembrane protein containing a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 218 amino acid extracellular domain. Recombinant human soluble BAFF is a 152 amino acid polypeptide (17.0 kDa), which contains the TNF-like portion of the extracellular domain of BAFF. Manufactured using all non-animal reagents.

Additional Information

Source:
E. Coli
 
Purity:
Above 95% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Mouse
 
Biological Activity
Determined by a mouse splenocyte survival assay. The expected ED50 for this effect is 0.5-2.0 µg/ml.
 
AA Sequence
AVQGPEETV TQDCLQLIA DSETPTIQK GSYTFVPWL LSFKRGSAL EEKENKILV KETGYFFIY GQVLYTDKT YAMGHLIQR KKVHVFGDE LSLVTLFRC IQNMPETLP NNSCYSAGI AKLEEGDEL QLAIPRENA QISLDGDVT FFGALKLL
Research Interest: Stem Cell Research, Apoptosis, Immunology
Cell Type: B Cells, Monocytes and Macrophages, T Cells, Dendritic Cells
Protein Cross Reactivity: Mouse

Availability: In stock

Size Price Qty
20µg
$215.00
100µg
$935.00
500µg
$3,420.00
1mg
$5,700.00