ALK5 Inhibitor (RepSox) hydrochloride
description
The ALK5 inhibitor selectively inhibits TGF-Beta receptor signaling, useful for enhancing the efficiency of cellular reprogramming. It is also reported to induce the differentiation of pancreatic progenitor cells into insulin-producing cells.
Additional Information
Applications: | FA |
Synonyms: | RepSox, ALK5 Inhibitor II, E616452 |
Formulation: | Crystalline solid |
Chemical Name: | 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine, monohydrochloride |
Molecular Formula: | C17H13N5 HCl |
Molecular Weight: | 323.8 |
CAS Number | 2319939-07-4 |
Purity: | ≥98% |
Storage Conditions: | Product should be kept at -20°C. |
References: | Woltjen, K., & Stanford, W. L. (2009). Inhibition of Tgf-β Signaling Improves Mouse Fibroblast Reprogramming. Cell stem cell, 5(5), 457-458. Larsen, D. M. (2013). Evaluation of the TGF-beta inhibitor RepSox on the expression of pluripotency pathways in murine and bovine cells. UTAH STATE UNIVERSITY. Jajosky, A. N., Coad, J. E., Vos, J. A., Martin, K. H., Senft, J. R., Wenger, S. L., & Gibson, L. F. (2014). RepSox Slows Decay of CD34+ Acute Myeloid Leukemia Cells and Decreases T Cell Immunoglobulin Mucin-3 Expression.Stem cells translational medicine, 3(7), 836. |