AG 1478
Catalog Number : 1535346
description
AG 1478 is a potent and selective epidermal growth factor receptor (EGFR) kinase inhibitor. It is reported to inhibit cell proliferation and arrests cell cycle in nasopharyngeal carcinoma cells and a suppressor of leiomyoma cell growth.
Additional Information
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Applications:
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FA
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Synonyms:
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AG1478, AG-1478, tyrphostin-AG1478, TYRPHOSTIN
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Formulation:
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Crystalline solid
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Chemical Name:
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N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine
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Molecular Formula:
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C16H14ClN3O2 |
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Molecular Weight: |
315.8
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CAS Number
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153436-53-4
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Zhu, X. F., Liu, Z. C., Xie, B. F., Li, Z. M., Feng, G. K., Yang, D., & Zeng, Y. X. (2001). EGFR tyrosine kinase inhibitor AG1478 inhibits cell proliferation and arrests cell cycle in nasopharyngeal carcinoma cells. Cancer letters, 169(1), 27-32. Zhang, Y. G., Du, Q., Fang, W. G., Jin, M. L., & Tian, X. X. (2008). Tyrphostin AG1478 suppresses proliferation and invasion of human breast cancer cells. International journal of oncology, 33(3), 595-602. Caja, L., Sancho, P., Bertran, E., Ortiz, C., Campbell, J. S., Fausto, N., & Fabregat, I. (2011). The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms. Biochemical pharmacology, 82(11), 1583-1592. |