A 83-01
Catalog Number : 9094360
description
A 83-01 is a potent activing receptor-like kinase inhibitor (ALK4 IC50 45nM, ALK5 IC50 12nM, ALK7 IC50 7.5nM). It is a more potent inhibitor of ALK5 than SB 431542 and is reported to inhibit Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. However, A 83-01 had little or no effect on bone morphogenetic protein type I receptors, p38 mitogen-activated protein kinase, or extracellular regulated kinase. It is used to inhibit differentiation in iPSCs and maintain in vitro cellular self-renewal.
Additional Information
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Applications:
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FA
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Synonyms:
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A-83-01; A83-01; ALK5 Inhibitor IV; Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor IV, A083
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Formulation:
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Crystalline solid
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Chemical Name:
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3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide
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Molecular Formula:
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C25H19N5S |
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Molecular Weight: |
421.5
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CAS Number
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909910-43-6
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Tojo, M., Hamashima, Y., Hanyu, A., Kajimoto, T., Saitoh, M., Miyazono, K., ... & Imamura, T. (2005). The ALK‐5 inhibitor A‐83‐01 inhibits Smad signaling and epithelial‐to‐mesenchymal transition by transforming growth factor‐β. Cancer science, 96(11), 791-800. Li, W., Wei, W., Zhu, S., Zhu, J., Shi, Y., Lin, T., ... & Ding, S. (2009). Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell stem cell, 4(1), 16-19. Zhu, S., Li, W., Zhou, H., Wei, W., Ambasudhan, R., Lin, T., ... & Ding, S. (2010). Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell stem cell, 7(6). |