A 83-01
Catalog Number : 9094360
description
A 83-01 is a potent activing receptor-like kinase inhibitor (ALK4 IC50 45nM, ALK5 IC50 12nM, ALK7 IC50 7.5nM). It is a more potent inhibitor of ALK5 than SB 431542 and is reported to inhibit Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. However, A 83-01 had little or no effect on bone morphogenetic protein type I receptors, p38 mitogen-activated protein kinase, or extracellular regulated kinase. It is used to inhibit differentiation in iPSCs and maintain in vitro cellular self-renewal.
Additional Information
Applications: | FA |
Synonyms: | A-83-01; A83-01; ALK5 Inhibitor IV; Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor IV, A083 |
Formulation: | Crystalline solid |
Chemical Name: | 3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide |
Molecular Formula: | C25H19N5S |
Molecular Weight: | 421.5 |
CAS Number | 909910-43-6 |
Purity: | ≥95% |
Storage Conditions: | Product should be kept at -20°C. |
References: | Tojo, M., Hamashima, Y., Hanyu, A., Kajimoto, T., Saitoh, M., Miyazono, K., ... & Imamura, T. (2005). The ALK‐5 inhibitor A‐83‐01 inhibits Smad signaling and epithelial‐to‐mesenchymal transition by transforming growth factor‐β. Cancer science, 96(11), 791-800. Li, W., Wei, W., Zhu, S., Zhu, J., Shi, Y., Lin, T., ... & Ding, S. (2009). Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell stem cell, 4(1), 16-19. Zhu, S., Li, W., Zhou, H., Wei, W., Ambasudhan, R., Lin, T., ... & Ding, S. (2010). Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell stem cell, 7(6). |