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A 83-01



Catalog Number : 9094360

Description

A 83-01 is a potent activing receptor-like kinase inhibitor (ALK4 IC50 45nM, ALK5 IC50 12nM, ALK7 IC50 7.5nM). It is a more potent inhibitor of ALK5 than SB 431542 and is reported to inhibit Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. However, A 83-01 had little or no effect on bone morphogenetic protein type I receptors, p38 mitogen-activated protein kinase, or extracellular regulated kinase. It is used to inhibit differentiation in iPSCs and maintain in vitro cellular self-renewal.
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Additional Information

Applications:
FA
Synonyms:
A-83-01; A83-01; ALK5 Inhibitor IV; Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor IV, A083
Formulation:
Crystalline solid
Chemical Name:
3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide
Molecular Formula:

C25H19N5S

Molecular Weight:
421.5
CAS Number
909910-43-6
Purity:
≥95%
Storage Conditions:
Product should be kept at -20°C.
References:

Tojo, M., Hamashima, Y., Hanyu, A., Kajimoto, T., Saitoh, M., Miyazono, K., ... & Imamura, T. (2005). The ALK‐5 inhibitor A‐83‐01 inhibits Smad signaling and epithelial‐to‐mesenchymal transition by transforming growth factor‐β. Cancer science96(11), 791-800.

Li, W., Wei, W., Zhu, S., Zhu, J., Shi, Y., Lin, T., ... & Ding, S. (2009). Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell stem cell4(1), 16-19.

Zhu, S., Li, W., Zhou, H., Wei, W., Ambasudhan, R., Lin, T., ... & Ding, S. (2010). Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell stem cell7(6).


Availability: In stock

Size Price Qty
10mg
$105.00
25mg
$245.00