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8-Bromo-cAMP



Catalog Number : 2354843

Description

8-Bromo-cAMP is a cell-permeable brominated derivative of cAMP that is longer lasting due to a higher resistance to cyclic AMP phosphodiesterase. cAMP activates protein kinases, used for intracellular signal transduction, and regulates the function of ion channels. 8-Bromo-cAMP is reported to enhance the induction of pluripotency in human fibroblast cells and protects neutrophils against TNF-α-induced apoptosis.
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Additional Information

Applications
FA
Synonyms:
8 Bromo cAMP; 8 Bromo Cyclic Adenosine Monophosphate; 8 Bromo Cyclic AMP; 8 Bromo Cyclic Adenosine Monophosphate; Br Cycl AMP
Formulation:
Crystalline solid
Chemical Name:
(4aR,6R,7R,7aS)-6-(6-amino-8-bromopurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
Molecular Formula:

C10H11BrN5PO6

Molecular Weight:
408.1
CAS Number
23583-48-4
Purity:
≥95%
Storage Conditions:
Product should be kept at -20°C.
References:

Rydel, R. E., & Greene, L. A. (1988). cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor. Proceedings of the National Academy of Sciences85(4), 1257-1261.

Ringler, G. E., Lee-Chuan, K., Miller, W. L., & Strauss, J. F. (1989). Effects of 8-bromo-cAMP on expression of endocrine functions by cultured human trophoblast cells. Regulation of specific mRNAs. Molecular and cellular endocrinology61(1), 13-21.

Wang, Y., & Adjaye, J. (2011). A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Reviews and Reports7(2), 331-341.


Availability: In stock

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25mg
$100.00
100mg
$300.00