3-Methyladenine
Catalog Number : 5142342
description
3-Methyladenine is a phosphatidylinositol 3-kinase (PI3k) inhibitor, blocking class I, class II, and class III PI3ks. This small molecule is reported to inhibit autophagy and apoptosis. The ability of 3-methyladenine to suppress the formation of electron microscopically visible autophagosomes suggests that it may be regarded as a specific inhibitor of autophagy.
Additional Information
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Applications:
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FA
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Synonyms:
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3-MA, N(3)-methyladenine
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Formulation:
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Crystalline solid
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Chemical Name:
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3-methylpurin-6-amine
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Molecular Formula:
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C6H7N5 |
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Molecular Weight: |
149.2
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CAS Number
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5142-23-4
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Seglen, P. O., & Gordon, P. B. (1982). 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes.Proceedings of the National Academy of Sciences, 79(6), 1889-1892. Wu, Y. T., Tan, H. L., Shui, G., Bauvy, C., Huang, Q., Wenk, M. R., ... & Shen, H. M. (2010). Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. Journal of Biological Chemistry, 285(14), 10850-10861. CARO, L. H. P., PLOMP, P. J., WOLVETANG, E. J., KERKHOF, C., & MEIJER, A. J. (1988). 3‐Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism. European Journal of Biochemistry, 175(2), 325-329. |