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3-Methyladenine



Catalog Number : 5142342

Description

3-Methyladenine is a phosphatidylinositol 3-kinase (PI3k) inhibitor, blocking class I, class II, and class III PI3ks. This small molecule is reported to inhibit autophagy and apoptosis. The ability of 3-methyladenine to suppress the formation of electron microscopically visible autophagosomes suggests that it may be regarded as a specific inhibitor of autophagy.
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Additional Information

Applications:
FA
Synonyms:
3-MA, N(3)-methyladenine
Formulation:
Crystalline solid
Chemical Name:
3-methylpurin-6-amine
Molecular Formula:

C6H7N5

Molecular Weight:
149.2
CAS Number
5142-23-4
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Seglen, P. O., & Gordon, P. B. (1982). 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes.Proceedings of the National Academy of Sciences79(6), 1889-1892.

Wu, Y. T., Tan, H. L., Shui, G., Bauvy, C., Huang, Q., Wenk, M. R., ... & Shen, H. M. (2010). Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. Journal of Biological Chemistry285(14), 10850-10861.

CARO, L. H. P., PLOMP, P. J., WOLVETANG, E. J., KERKHOF, C., & MEIJER, A. J. (1988). 3‐Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism. European Journal of Biochemistry175(2), 325-329.


Availability: In stock

Size Price Qty
50mg
$55.00
100mg
$100.00