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3-Deazaneplanocin A



Catalog Number : 1029595

Description

3-Deazaneplanocin A is an epigenetic modifier, inhibiting histone h3 lysine 27. The mechanism for this action is the inhibition of lysine methyltransferases, especially EZH2. It is reported to induce apoptosis in cancer cells to the exclusion of normal cells and useful in the generation of chemically induced pluripotent stem cells (CiPSCs).
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Additional Information

Applications
FA
Synonyms:
DZNep, NSC 617989
Formulation:
Crystalline solid
Chemical Name:
(1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol
Molecular Formula:

C12H14N4O3

Molecular Weight:
262.3
CAS Number
102052-95-9
Purity:
≥97%
Storage Conditions:
Product should be kept at -20°C.
References:

Fiskus, W., Wang, Y., Sreekumar, A., Buckley, K. M., Shi, H., Jillella, A., ... & Bhalla, K. N. (2009). Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood114(13), 2733-2743.

Glazer, R. I., Hartman, K. D., Knode, M. C., Richard, M. M., Chiang, P. K., Tseng, C. K., & Marquez, V. E. (1986). 3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60. Biochemical and biophysical research communications135(2), 688-694.

Bray, M., Raymond, J. L., Geisbert, T., & Baker, R. O. (2002). 3-Deazaneplanocin A induces massively increased interferon-α production in Ebola virus-infected mice. Antiviral research55(1), 151-159.


Availability: In stock

Size Price Qty
1mg
$160.00
5mg
$435.00