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25-hydroxy Cholesterol



Catalog Number : 2144674

Description

25-hydroxy Cholesterol is a dietary cholesterol derivative with a side chain substituted oxysterol that is capable of triggering the activation of many cholesterol molecules. It has been reported to activate ABCA1 signaling, atherosclerosis modulation, and induces apoptosis in human cell lines through caspases activation and bcl-2 downregulation. 25-hydroxy Cholesterol is immunomodulating and is capable of suppressing macrophage differentiation from monocytes.
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Additional Information

Applications
FA
Synonyms:
25-hydroxycholesterol, (3beta)-isomer, 5-cholestene-3beta,25-diol
Formulation:
Crystalline solid
Chemical Name:
(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
Molecular Formula:

C27H46O2

Molecular Weight:
402.7
CAS Number
2140-46-7
Purity:
≥98%
Storage Conditions:
Product should be kept at-20°C.
References:

Peng, S. K., Taylor, C. B., Hill, J. C., & Morin, R. J. (1985). Cholesterol oxidation derivatives and arterial endothelial damage. Atherosclerosis54(2), 121-133.

Erickson, S. K., Matsui, S. M., Shrewsbury, M. A., Cooper, A. D., & Gould, R. G. (1978). Effects of 25-hydroxycholesterol on rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in vivo, in perfused liver, and in hepatocytes. Journal of Biological Chemistry253(12), 4159-4164.

Aupeix, K., Weltin, D., Mejia, J. E., Christ, M., Marchal, J., Freyssinet, J. M., & Bischoff, P. (1995). Oxysterol-induced apoptosis in human monocytic cell lines. Immunobiology194(4), 415-428.


Availability: In stock

Size Price Qty
5mg
$35.00
25mg
$120.00