IQ-1
Catalog Number : 3316280
description
IQ-1 is a selective inhibitor of Beta-catenin/p300 signaling by binding to protein phosphatase 2. It is used to maintain embryonic cell pluripotency in Wnt3a-treated cells and prevent spontaneous differentiation. It is also reported to upregulate the expression of Sox2 and Oct4 transcription factors.
Additional Information
Applications:
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FA
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Synonyms:
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ST50223451, MLS000559249, AC1NY3UK, CHEMBL3193709
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Formulation:
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Crystalline solid
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Chemical Name:
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(2E)-2-[(4-acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4H-isoquinolin-1-yl)acetamide
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Molecular Formula:
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C21H22N4O2 |
Molecular Weight: |
362.4
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CAS Number
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331001-62-8
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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cMiyabayashi, T., Teo, J. L., Yamamoto, M., McMillan, M., Nguyen, C., & Kahn, M. (2007). Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proceedings of the National Academy of Sciences, 104(13), 5668-5673. Chase, L. G., & Firpo, M. T. (2007). Development of serum-free culture systems for human embryonic stem cells. Current opinion in chemical biology,11(4), 367-372. Miki, T., Yasuda, S. Y., & Kahn, M. (2011). Wnt/β-catenin signaling in embryonic stem cell self-renewal and somatic cell reprogramming. Stem Cell Reviews and Reports, 7(4), 836-846. |