Anti-Human CD16 SAFIRE Purified
Additional 3G8 Formats
| Cat.No. | Format | Starting From |
|---|---|---|
| 08221-25 | SAFIRE Purified | $ 220.00 |
| 08221-60 | PE | $ 110.00 |
Catalog Number : 08221-25
description
The 3G8 monoclonal antibody specifically reacts with human CD16, the low affinity IgG receptor III (FC gamma RIII). CD16 is expressed on granulocytes, monocytes, macrophages, and NK cells and plays a role in NK activation and signal transduction. CD16 is expressed as either CD16a or CD16b. CD16a is a polypeptide-anchored transmembrane protein and CD16b is a glycosylphosphatidylinositol (GPI)-anchored protein that is expressed exclusively on neutrophils.
Additional Information
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Clone:
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3G8
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Format:
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SAFIRE Purified
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Applications:
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FC, FA
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Reactivity:
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Human
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Isotype:
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Mouse IgG1, kappa
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| Research Interest: | Innate Immunity |
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| Cell Type: | Macrophage / Monocyte, NK and NKT Cells |
| Application: | FC, FA |
| Clone: | 3G8 |
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Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2
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References:
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Choi, E. I., Wang, R., Peterson, L., Letvin, N. L., Reimann, K. A. (2008). Use of an anti‐CD16 antibody for in vivo depletion of natural killer cells in rhesus macaques. Immunology, 124(2), 215-222.
Perussia, B. I. C. E., & Trinchieri, G. I. O. R. G. I. O. (1984). Antibody 3G8, specific for the human neutrophil Fc receptor, reacts with natural killer cells. The Journal of Immunology, 132(3), 1410-1415. Vossebeld, P. J., Homburg, C. H., Roos, D., & Verhoeven, A. J. (1997). The anti-FcγRIII mAb 3G8 induces neutrophil activation via a cooperative action of FcγRIIIb and FcγRIIa. The international journal of biochemistry & cell biology,29(3), 465-473. |