Anti-Rat CD86 (B7-2) FITC
description
The 24F monoclonal antibody specifically reacts with CD86 (B7-2), a 90 kDA surface receptor present on antigen presenting cells and activated B and T cells. CD86 is a ligand for CD28 and CD152 and plays an essential role in B cell-T cell costimulatory interactions.
The 24F antibody is capable of blocking the co-stimulatory activity of CD86.
Additional Information
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Clone:
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24F
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Format:
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FITC
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Applications:
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FC
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Reactivity:
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Rat
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Isotype:
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Mouse IgG1, kappa
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| Research Interest: | Innate Immunity |
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| Cell Type: | Dendritic Cells |
| Application: | FC |
| Clone: | 24F |
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Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Maeda, K., Sato, T., Azuma, M., Yagita, H., & Okumura, K. (1997). Characterization of rat CD80 and CD86 by molecular cloning and mAb.International immunology, 9(7), 993-1000. Damoiseaux, J. G., Yagita, H., Okumura, K., & van Breda Vriesman, P. J. (1998). Costimulatory molecules CD80 and CD86 in the rat; tissue distribution and expression by antigen-presenting cells. Journal of leukocyte biology, 64(6), 803-809. BLUESTONE, J. (1995). New perspectives of CD28-B7-mediated T cell costimulation. Immunity, 2, 555-559. |