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Anti-Mouse Ly-6G (Gr-1) SAFIRE Purified



Catalog Number : 83122-25

Description

The RB6-8C5 monoclonal antibody reacts with the mouse Ly-6G (also known as Gr-1). The Ly-6G protein is a myeloid differentiation antigen of 21-25 kDa, expressed in a regulated manner by the myeloid lineage in the bone marrow, where the level of antigen expression is correlated with the granulocyte maturation and differentiation. In the bone marrow, the antigen is not expressed by the erythroid cells.

From the peripheric cells, RB6-8C5 binds with monocytes, neutrophils and eosinophils.

As a marker for the mouse monocytes, macrophages and granulocytes, the RB6-8C5 antibody is usually combined with M1/70, a macrophage labeling antibody (Anti-CD11b), for phenotypic analysis.

Additional Information

Clone
RB6-8C5
Format:
SAFIRE Purified
Applications
FC, FA, IHC, IP
Reactivity
Mouse
Isotype:
Rat IgG2b, kappa
Research Interest: Innate Immunity
Cell Type: Monocytes and Macrophages
Preperation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Fleming, T. J., Fleming, M. L., & Malek, T. R. (1993). Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family.The Journal of Immunology151(5), 2399-2408.

Hestdal, K., Ruscetti, F. W., Ihle, J. N., Jacobsen, S. E., Dubois, C. M., Kopp, W. C., ... & Keller, J. R. (1991). Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells. The Journal of Immunology,147(1), 22-28.

Huang, B., Zhao, J., Shen, S., Li, H., He, K. L., Shen, G. X., ... & Feng, Z. H. (2007). Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling. Cancer Research67(9), 4346-4352.


Availability: In stock

Size Price Qty
100 μg
$135.00
500 μg
$230.00
1 mg
$440.00
Additional RB6-8C5 Formats
Cat.No. Format Starting From
83122-60PE $ 45.00
83122-77PE-Cyanine7 $ 70.00
83122-20Purified $ 70.00
83122-25SAFIRE Purified $ 135.00
83122-50FITC $ 35.00
83122-30Biotin $ 30.00
83122-80APC $ 50.00
83122-40BG Violet 450 $ 80.00