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Anti-Mouse LPAM-1 APC



Catalog Number : 83212-80

Description

The DATK32 monoclonal antibody specifically reacts with an epitoPEof the Mouseα4β7 integrin (LPAM-1). The two subunits of the LPAM-1 heterodimer are the 154 kDa α4 and the 130 kDa β7. Most mature lymphocytes, a subset of bone marrow cells, and some of the thymic cells express the α4β7 integrin heterodimer. α4β7 enhances the transendothelial migration of lymphocytes, and interacts with several ligands (fibronectin, CD106, and MAdCAM-1). The interaction of DATK32 with the α4β7 induces the α4β7-dependent lymphocyte aggregation and inhibits LPAM-1-dediated cell adhesion.

Additional Information

Clone
DATK32
Format:
APC
Applications
FC
Reactivity
Mouse
Isotype:
Rat IgG2a, kappa
Research Interest: Adaptive Immunity, Angiogenesis
Cell Type: B Cells, NK and NKT Cells, T Cells
Preperation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Andrew, D. P., Berlin, C., Honda, S., Yoshino, T., Hamann, A., Holzmann, B., ... & Butcher, E. C. (1994). Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation. The Journal of Immunology153(9), 3847-3861.

Berlin, C., Berg, E. L., Briskin, M. J., Andrew, D. P., Kilshaw, P. J., Holzmann, B., ... & Butcher, E. C. (1993). α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell74(1), 185-195.

Rivera-Nieves, J., Olson, T., Bamias, G., Bruce, A., Solga, M., Knight, R. F., ... & Ley, K. (2005). L-selectin, α4β1, and α4β7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine. The Journal of Immunology,174(4), 2343-2352.


Availability: In stock

Size Price Qty
25 μg
$80.00
100 μg
$225.00
Additional DATK32 Formats
Cat.No. Format Starting From
83212-30Biotin $ 40.00
83212-60PE $ 80.00
83212-80APC $ 80.00