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Anti-Mouse IL-12/IL-23 p40 SAFIRE Purified



Catalog Number : 83312-25

Description

The C17.8 antibody specifically reacts with the p40 subunit of IL-12, as free monomer, as a homodimer, or as a part of the p70 dimer. C17.8 seems to neutralize the activity of mouse IL-12 and IL-23. IL-12 is the p70 heterodimer of p35 and p40, expressed by the macrophages, dendritic cells, and monocytes. The C17.8 antibody cross-reacts with IL-23, since IL-23 also contains one p40 subunit.

Additional Information

Clone
C17.8
Format:
SAFIRE Purified
Applications
FC, FA, IF, IP, WB, ELISA
Reactivity
Mouse
Isotype:
Rat IgG2a, kappa
Research Interest: Innate Immunity
Cell Type: Monocytes and Macrophages, T Cells, Dendritic Cells
Preperation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Wysocka, M., Kubin, M., Vieira, L. Q., Ozmen, L., Garotta, G., Scott, P., & Trinchieri, G. (1995). Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. European journal of immunology, 25(3), 672-676.

Cho, D., Lee, W. J., Halloran, P. J., Trinchieri, G., & Kim, Y. B. (1996). Enhancement of porcine natural killer cell activity by recombinant human and murine IL-12. Cellular immunology172(1), 29-34.

D'Andrea, A., Rengaraju, M., Valiante, N. M., Chehimi, J., Kubin, M., Aste, M., ... & Nickbarg, E. (1992). Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. The Journal of experimental medicine176(5), 1387-1398.


Availability: In stock

Size Price Qty
100 μg
$205.00
500 μg
$260.00
Additional C17.8 Formats
Cat.No. Format Starting From
83312-60PE $ 80.00
83312-25SAFIRE Purified $ 205.00