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Anti-Mouse Fc epsilon Receptor I alpha (FceR1) Purified



Catalog Number : 84112-20

Description

The Mar-1 monoclonal antibody binds to the Fc ε Receptor I α subunit (FceR1a), which is a transmembrane glycoprotein from the immunoglobulin superfamily. FceR1a lacks signal-transducing ability and is expressed by mast and basophil cells.

The Fc ε Receptor I α subunit is upregulated by IgE and forms a tetramer with a beta subunit and two gamma subunits, which have ITAM (immunoreceptor tyrosine-based activation motifs). The complex formed by the four subunits has very important roles in the IgE-facilitated allergic reactions.

Additional Information

Clone
MAR-1
Format:
Purified
Applications
FC, FA, IHC, IP
Reactivity
Mouse
Isotype:
Armenian Hamster IgG
Research Interest: Innate Immunity
Cell Type: Monocytes and Macrophages
Preperation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Joncker, N. T., Fernandez, N. C., Treiner, E., Vivier, E., & Raulet, D. H. (2009). NK cell responsiveness is tuned commensurate with the number of inhibitory receptors for self-MHC class I: the rheostat model. The Journal of Immunology,182(8), 4572-4580.

Obata, K., Mukai, K., Tsujimura, Y., Ishiwata, K., Kawano, Y., Minegishi, Y., ... & Karasuyama, H. (2007). Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood110(3), 913-920.

Arinobu, Y., Iwasaki, H., Gurish, M. F., Mizuno, S. I., Shigematsu, H., Ozawa, H., ... & Akashi, K. (2005). Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proceedings of the National Academy of Sciences of the United States of America102(50), 18105-18110.


Availability: In stock

Size Price Qty
100 μg
$120.00
Additional MAR-1 Formats
Cat.No. Format Starting From
84112-60PE $ 60.00
84112-20Purified $ 120.00
84112-25SAFIRE Purified $ 160.00
84112-50FITC $ 50.00