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Anti-Mouse CD90.2 APC



Catalog Number : 03012-80

Description

The 30-H12 monoclonal antibody specifically binds to MouseCD90.2, an alloantigen known as Thy-1.2, expressed on thymocytes, mature T cells, epithelial cells, neurons, hematopoietic stem cells, and fibroblasts. CD90 is a membrane glycoprotein that regulates the adhesion and signal transduction in T lymphocytes, and the adhesion of thymocytes to thymic stroma.

The interaction between 30-H12 and the antibody to the CD3/TCR complex upregulates thymocytes signal transduction and apoptosis and downregulates mature T cell proliferation. The 30-H12 antibody seems to be unable to cross-link with CD90.1.

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C57Bl/6 splenocytes were stained with APC 30-H12 with relevant isotype control in Red.
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Additional Information

Clone
30-H12
Format:
APC
Applications
FC
Reactivity
Mouse
Isotype:
Rat IgG2b
Research Interest: Adaptive Immunity
Cell Type: T Cells
Preperation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Ledbetter, J. A., & Herzenberg, L. A. (1979). Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*. Immunological reviews47(1), 63-90.

Radrizzani, M., Carminatti, H., Pivetta, O. H., & Vargas, V. P. (1995). Developmental regulation of Thy 1.2 rate of synthesis in the mouse cerebellum.Journal of neuroscience research42(2), 220-227.

Seaman, W. E., Wofsy, D., Greenspan, J. S., & Ledbetter, J. A. (1983). Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease.The Journal of Immunology130(4), 1713-1718.


Availability: In stock

Size Price Qty
25 μg
$65.00
100 μg
$205.00
Additional 30-H12 Formats
Cat.No. Format Starting From
03012-50FITC $ 25.00
03012-77PE-Cyanine7 $ 95.00
03012-80APC $ 65.00
03012-40BG Violet 450 $ 75.00
03012-25SAFIRE Purified $ 100.00