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Anti-Mouse CD45.1 PerCP-Cyanine5.5



Catalog Number : 07522-70

Description

The A20 monoclonal antibody reacts with the leukocytes of the CD45.1-expressing mouse strains (DA, SJL/J, RIII, and STS/A). It does not cross-react with cells that express CD45.2.

The CD45 molecule is a member of the Protein Tyrosine Phosphatase (PTP) family, because its intracellular region contains two PTP domains. The extracellular region’s variability is caused by different levels of glycosylation, and the splicing of the 4, 5, and 6 exons. The isoforms found in the mouse strains depend on the activation state, maturation stage and cell type, and are very important in B and T lymphocytes antigen receptor signal transduction.

The A20 antibody inhibits some of the B lymphocytes responses, from CD45.1-expressing mice, to lipopolysaccharides and antigens.

Additional Information

Clone
A20
Format:
PerCP-Cyanine5.5
Applications
FC
Reactivity
Mouse
Isotype:
Mouse IgG2a, kappa
Research Interest: Adaptive Immunity
Cell Type: B Cells, Monocytes and Macrophages, NK and NKT Cells, T Cells
Preperation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Shen, F.W. (1981) Monoclonal antibodies to mouse lymphocyte differentiation alloantigens. Monoclonal Antibodies and T-Cell Hybridomas: Perspectives and Technical Advances. G.J. Hämmerling, U. Hämmerling, and J.F. Kearney, editors. Elsevier/North-Holland, Amsterdam. pp. 25–31.

Yakura, H. I. D. E. T. A. K. A., Kawabata, I., Shen, F. W., & Katagiri, M. (1986). Selective inhibition of lipopolysaccharide-induced polyclonal IgG response by monoclonal Ly-5 antibody. The Journal of Immunology136(8), 2729-2733.

Yakura, H., Shen, F. W., Bourcet, E., & Boyse, E. A. (1983). On the function of Ly-5 in the regulation of antigen-driven B cell differentiation. Comparison and contrast with Lyb-2. The Journal of experimental medicine157(4), 1077-1088.


Availability: In stock

Size Price Qty
25 μg
$90.00
100 μg
$250.00
Additional A20 Formats
Cat.No. Format Starting From
07522-60PE $ 65.00
07522-70PerCP-Cyanine5.5 $ 90.00
07522-77PE-Cyanine7 $ 55.00
07522-40BG Violet 450 $ 80.00
07522-20Purified $ 80.00
07522-50FITC $ 45.00
07522-87APC-Cyanine7 $ 90.00
07522-80APC $ 70.00