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Anti-Mouse CD3 APC



Catalog Number : 05112-80

Description

The 17A2 monoclonal antibody specifically reacts with the MouseT lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation. CD3 is expressed by thymocytes and mature lymphocytes, and contains γ, δ, and ε subunits, involved in the assembly, trafficking, and surface expression of T-cell receptor complex.

The interaction between the T lymphocytes and the 17A2 antibody can be blocked by the 145-2C11 anti-CD3e antibody, demonstrating that the 17A2 antibody recognizes the CD3 ε chain.

Additional Information

Clone
17A2
Format:
APC
Applications
FC
Reactivity
Mouse
Isotype:
Rat IgG2b, kappa
Research Interest: Adaptive Immunity
Cell Type: NK and NKT Cells, T Cells, Treg cells, Th17 cells
Preperation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Miescher, G. C., Schreyer, M., & MacDonald, H. R. (1989). Production and characterization of a rat monoclonal antibody against the murine CD3 molecular complex. Immunology letters23(2), 113-118.

Mysliwietz, J., & Thierfelder, S. (1992). Antilymphocytic antibodies and marrow transplantation. XII. Suppression of graft-versus-host disease by T-cell-modulating and depleting antimouse CD3 antibody is most effective when preinjected in the marrow recipient. Blood80(10), 2661-2667.

Wu, L., Antica, M., Johnson, G. R., Scollay, R., & Shortman, K. (1991). Developmental potential of the earliest precursor cells from the adult mouse thymus. The Journal of experimental medicine174(6), 1617-1627.


Availability: In stock

Size Price Qty
25 μg
$60.00
100 μg
$135.00
Additional 17A2 Formats
Cat.No. Format Starting From
05112-87APC-Cyanine7 $ 85.00
05112-40BG Violet 450 $ 75.00
05112-20Purified $ 20.00
05112-25SAFIRE Purified $ 105.00
05112-60PE $ 55.00
05112-80APC $ 60.00
05112-50FITC $ 25.00