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Anti-Mouse CD28 Purified



Catalog Number : 10312-20

Description

The 37.51 monoclonal antibody specifically reacts with mouse CD28 molecule, a 45 kDa homodimer. It is expressed on most thymocytes, at low density on most of the CD4+ and CD8+ peripheral T lymphocytes, and on the natural killer cells. It is additionally found on activated splenocytes, mast cells, and thymocytes. CD 28 is a costimulator of T lymphocytes and a ligand for CD80 (B7-1), and CD86 (B7-2). The CD28 signaling stimulates the expression of IL-2 and IL-2 receptor and the cytotoxicity of CD3-activated T lymphocytes.

The 37.51 antibody stimulates the proliferation of T lymphocytes and natural killer cells and their respective cytokine production.

Additional Information

Clone
37.51
Format:
Purified
Applications
FC, FA, IP
Reactivity
Mouse
Isotype:
Golden Syrian Hamster IgG
Research Interest: Adaptive Immunity
Cell Type: T Cells
Preperation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Nandi, D., Gross, J. A., & Allison, J. P. (1994). CD28-mediated costimulation is necessary for optimal proliferation of murine NK cells. The Journal of Immunology152(7), 3361-3369.

Gross, J. A., Callas, E. L. E. N. I., & Allison, J. P. (1992). Identification and distribution of the costimulatory receptor CD28 in the mouse. The Journal of Immunology149(2), 380-388.

Grossi, J. A., Raulet, D. H., & Allison, J. P. (1992). CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones.Nature356, 607-9.

Nishio, M., Spielman, J., Lee, R. K., Nelson, D. L., & Podack, E. R. (1996). CD80 (B7. 1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis. The Journal of Immunology,157(10), 4347-4353.


Availability: In stock

Size Price Qty
100 μg
$85.00
500 μg
$200.00
Additional 37.51 Formats
Cat.No. Format Starting From
10312-20Purified $ 85.00
10312-25SAFIRE Purified $ 135.00
10312-60PE $ 110.00