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Anti-Mouse CD25 PerCP-Cyanine5.5



Catalog Number : 07312-70

Description

The PC61.5 antibody specifically reacts with mouse CD25, the 55 kDa low-affinity Interleukin-2 Receptor α chain (IL-2R α), expressed on early progenitors of T and B lineage, and on B and T cells. Together with CD122 (IL-2 Receptor β) and CD 132 (IL-2 Receptor γc, the common gamma chain), CD25 forms high-affinity receptor complexes for IL-2. Resting B and T cells and natural killer cells do not express IL-2Rα. Cd25 is also expressed on the dendritic cells, and it enhances lymphocyte differentiation and activation.

The PC61.5 antibody blocks the binding of IL-2 to both high-affinity and low-affinity receptors.

Additional Information

Clone
PC61.5
Format:
PerCP-Cyanine5.5
Applications
FC
Reactivity
Mouse
Isotype:
Rat IgG1, lambda
Research Interest: Adaptive Immunity
Cell Type: T Cells, B Cells, Treg cells
Preperation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Hayashi, T., Hasegawa, K., & Adachi, C. (2005). Elimination of CD4+ CD25+ T cell accelerates the development of glomerulonephritis during the preactive phase in autoimmune-prone female NZB× NZW F1 mice. International journal of experimental pathology86(5), 289-296.

Lowenthal, J. W., Tougne, C., MacDonald, H. R., Smith, K. A., & Nabholz, M. (1985). Antigenic stimulation regulates the expression of IL 2 receptors in a cytolytic T lymphocyte clone. The Journal of Immunology134(2), 931-939.

Huang, B., Zhao, J., Shen, S., Li, H., He, K. L., Shen, G. X., ... & Feng, Z. H. (2007). Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling. Cancer Research67(9), 4346-4352.


Availability: In stock

Size Price Qty
25 μg
$90.00
100 μg
$265.00
Additional PC61.5 Formats
Cat.No. Format Starting From
07312-60PE $ 60.00
07312-70PerCP-Cyanine5.5 $ 90.00
07312-77PE-Cyanine7 $ 70.00
07312-40BG Violet 450 $ 90.00
07312-20Purified $ 65.00
07312-25SAFIRE Purified $ 120.00
07312-80APC $ 75.00
07312-50FITC $ 55.00