Anti-Mouse CD18 SAFIRE Purified
Additional M18/2 Formats
Cat.No. | Format | Starting From |
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10212-25 | SAFIRE Purified | $ 170.00 |
Catalog Number : 10212-25
description
The M18/2 monoclonal antibody specifically binds to mouse CD18, a 95kDA integrin beta 2 glycoprotein. CD18 is expressed on all leukocytes with the highest density by NK and T cells. CD18 forms LFA-1 with CD11a, Mac-1 with CD11b and gp150/95 with CD11c. Through these interactions, CD18 has an important role in cellular adhesion. The M18/2 antibody is reported to stimulate Mac-1 and LFA-1 adhesion to their ligands and block tumor cell metastasis.
Additional Information
Clone:
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M18/2
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Format:
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SAFIRE Purified
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Applications:
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FC, FA
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Reactivity:
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Mouse
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Isotype:
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Rat IgG2a, kappa
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Research Interest: | Angiogenesis |
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Cell Type: | T Cells, NK and NKT Cells |
Application: | FC, FA |
Clone: | M18/2 |
Preparation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Driessens, M. H., Van Hulten, P., Zuurbier, A., La Riviere, G., & Roos, E. (1996). Inhibition and stimulation of LFA-1 and Mac-1 functions by antibodies against murine CD18. Evidence that the LFA-1 binding sites for ICAM-1,-2, and-3 are distinct. Journal of leukocyte biology, 60(6), 758-765. Zahalka, M. A., & Naor, D. (1994). β2-lntegrin dependent aggregate formation between LB T cell lymphoma and spleen cells: assessment of correlation with spleen invasiveness. International immunology, 6(6), 917-924. Isobe, M., Yagita, H., Okumura, K., & Ihara, A. (1992). Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. Science,255(5048), 1125-1127. |