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Anti-Mouse CD16 / CD32 Purified



Catalog Number : 08212-20

Description

The 2.4G2 monoclonal antibody specifically reacts with an epitope on the extracellular domain of the mouse CD16 (Fc γ III) and CD 32 (Fc γ II). CD16 and CD32 are low affinity receptors for the IgG Fc domain and are expressed by B lymphocytes, NK cells, kupffer cells, mast cells, monocytes, macrophages, granulocytes, immature thymocytes, neutrophils, and some activated mature T cells.

The 2.4G2 antibody blocks the binding of immunoglobulins to CD16 and CD32, and possibly to Fc γ I receptor.

Additional Information

Clone
2.4G2
Format:
Purified
Applications
FC, FA, IF, IP
Reactivity
Mouse
Isotype:
Rat IgG2b
Research Interest: Innate Immunity
Cell Type: NK and NKT Cells, Monocytes and Macrophages
Preperation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Araujo-Jorge, T. A. N. I. A., Rivera, M. T., el Bouhdidi, A. Y. A. C. H. I., Daëron, M. A. R. C., & Carlier, Y. (1993). An Fc gamma RII-, Fc gamma RIII-specific monoclonal antibody (2.4 G2) decreases acute Trypanosoma cruzi infection in mice. Infection and immunity61(11), 4925-4928.

Jensen, W. A., Marschner, S., Ott, V. L., & Cambier, J. C. (2001). FcgammaRIIB-mediated inhibition of T-cell receptor signal transduction involves the phosphorylation of SH2-containing inositol 5-phosphatase (SHIP), dephosphorylation of the linker of activated T-cells (LAT) and inhibition of calcium mobilization. Biochemical Society Transactions29(Pt 6), 840-846.

Vremec, D., Zorbas, M., Scollay, R., Saunders, D. J., Ardavin, C. F., Wu, L., & Shortman, K. (1992). The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells. The Journal of experimental medicine176(1), 47-58.


Availability: In stock

Size Price Qty
100 μg
$100.00
500 μg
$230.00
1 mg
$370.00
Additional 2.4G2 Formats
Cat.No. Format Starting From
08212-20Purified $ 100.00
08212-25SAFIRE Purified $ 135.00
08212-50FITC $ 55.00