Creating Value for Life Science Research!


Get a Free Sample of this product!
shopping cart image

Anti-Mouse CD11c APC



Catalog Number : 03212-80

Description

The N418 monoclonal antibody specifically reacts with the integrin αx chain of the mouse CD11c, which is expressed on dendritic cells, CD4-/CD8+ intestinal intraepithelial lymphocytes (IEL) and some activated T lymphocytes. Low levels of CD11c were detected on mouse splenic natural killer cells and on the monocyte/macrophage lineage cells.

CD11c expression is upregulated on IEL and T lymphocytes after activation. It binds to CD54, fibrinogen and iC3b and influences the leukocyte adhesive interactions.

The N418 antibody binds to CD11c on splenic dendritic cells of the mouse in the T-dependent areas. It also contributes to the binding of iC3b.

Additional Information

Clone
N418
Format:
APC
Applications
FC
Reactivity
Mouse
Isotype:
Armenian Hamster IgG
Research Interest: Innate Immunity, Angiogenesis
Cell Type: Dendritic Cells, Monocytes and Macrophages
Preperation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Barclay, A. N., Brown, M. H., Law, S. A. K. A., McKnight, A. J., Tomlinson, M. G., & van der Merwe, P. A. (1997). The leucocyte antigen factsbook. Academic Press.

Pulendran, B., Lingappa, J., Kennedy, M. K., Smith, J., Teepe, M., Rudensky, A., ... & Maraskovsky, E. (1997). Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice. The Journal of Immunology159(5), 2222-2231.

Xin, K. Q., Mizukami, H., Urabe, M., Toda, Y., Shinoda, K., Yoshida, A., ... & Okuda, K. (2006). Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells. Journal of virology80(24), 11899-11910.


Availability: In stock

Size Price Qty
25 μg
$60.00
100 μg
$195.00
Additional N418 Formats
Cat.No. Format Starting From
03212-60PE $ 55.00
03212-70PerCP-Cyanine5.5 $ 90.00
03212-77PE-Cyanine7 $ 75.00
03212-40BG Violet 450 $ 80.00
03212-20Purified $ 100.00
03212-50FITC $ 45.00
03212-30Biotin $ 35.00
03212-87APC-Cyanine7 $ 75.00
03212-80APC $ 60.00