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Anti-Human/Mouse CD44 BG Violet 450



Catalog Number : 06511-40

Description

The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24). CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule.

The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice.

The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes.

BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.

Additional Information

Clone
IM7
Format:
BG Violet 450
Applications
FC
Reactivity
Human, Mouse
Isotype:
Rat IgG2b, kappa
Research Interest: Adaptive Immunity, Stem Cell Research, Angiogenesis
Cell Type: Monocytes and Macrophages
Preperation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Trowbridge, I. S., Lesley, J., Schulte, R., Hyman, R., & Trotter, J. (1982). Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues. Immunogenetics,15(3), 299-312.

Lesley, J., & Trowbridge, I. S. (1982). Genetic characterization of a polymorphic murine cell-surface glycoprotein. Immunogenetics15(3), 313-320.

Nedvetzki, S., Walmsley, M., Alpert, E., Williams, R. O., Feldmann, M., & Naor, D. (1999). CD44 involvement in experimental collagen-induced arthritis (CIA). Journal of autoimmunity13(1), 39-47.


Availability: In stock

Size Price Qty
25 μg
$80.00
100 μg
$175.00
Additional IM7 Formats
Cat.No. Format Starting From
06511-60PE $ 55.00
06511-65PE-Cyanine5 $ 70.00
06511-70PerCP-Cyanine5.5 $ 85.00
06511-40BG Violet 450 $ 80.00
06511-20Purified $ 130.00
06511-50FITC $ 55.00
06511-87APC-Cyanine7 $ 75.00
06511-80APC $ 60.00
06511-77PE-Cyanine7 $ 75.00
06511-25SAFIRE Purified $ 110.00