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Anti-Human/Mouse CD44 APC-Cyanine7



Catalog Number : 06511-87

Description

The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24). CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule.

The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice.

The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes.

Additional Information

Clone
IM7
Format:
APC-Cyanine7
Applications
FC
Reactivity
Human, Mouse
Isotype:
Rat IgG2b, kappa
Cell Type: Monocytes and Macrophages
Protein Cross Reactivity: Baboon, Canine, Chimpanzee, Cynomolgus, Equine, Feline, Rhesus, Swine
Preperation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Trowbridge, I. S., Lesley, J., Schulte, R., Hyman, R., & Trotter, J. (1982). Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues. Immunogenetics,15(3), 299-312.

Lesley, J., & Trowbridge, I. S. (1982). Genetic characterization of a polymorphic murine cell-surface glycoprotein. Immunogenetics15(3), 313-320.

Nedvetzki, S., Walmsley, M., Alpert, E., Williams, R. O., Feldmann, M., & Naor, D. (1999). CD44 involvement in experimental collagen-induced arthritis (CIA). Journal of autoimmunity13(1), 39-47.


Availability: In stock

Size Price Qty
25 μg
$75.00
100 μg
$205.00
Additional IM7 Formats
Cat.No. Format Starting From
06511-60PE $ 55.00
06511-65PE-Cyanine5 $ 70.00
06511-70PerCP-Cyanine5.5 $ 85.00
06511-40BG Violet 450 $ 80.00
06511-20Purified $ 130.00
06511-50FITC $ 55.00
06511-87APC-Cyanine7 $ 75.00
06511-80APC $ 60.00
06511-77PE-Cyanine7 $ 75.00
06511-25SAFIRE Purified $ 110.00