Anti-Human/Mouse CD11b SAFIRE Purified
Additional M1/70 Formats
Cat.No. | Format | Starting From |
---|---|---|
03221-60 | PE | $ 60.00 |
03221-65 | PE-Cyanine5 | $ 65.00 |
03221-70 | PerCP-Cyanine5.5 | $ 70.00 |
03221-20 | Purified | $ 90.00 |
03221-50 | FITC | $ 70.00 |
03221-30 | Biotin | $ 30.00 |
03221-87 | APC-Cyanine7 | $ 75.00 |
03221-80 | APC | $ 50.00 |
03221-77 | PE-Cyanine7 | $ 70.00 |
03221-40 | BG Violet 450 | $ 110.00 |
03221-25 | SAFIRE Purified | $ 135.00 |
description
The M1/70 monoclonal antibody specifically reacts with the 170 kDa αM integrin chain of mouse CD11b from the Mac-1 integrin (CD11b/CD18). Mac-1 binds to C3bi, CD54 (ICAM-1), and fibrinogen, and it is expressed by granulocytes, macrophages, NK cells, myeloid-derived dendritic cells, microglia, activated lymphocytes, and mouse B-1 cells. The expression is up-regulated on activated neutrophils at the same time that L-selectin is shed from the cell surface. The M1/70 antibody is used for the detection of monocytes, granulocytes, and a subset of natural killer cells in human peripheral blood.
M1/70 blocks C3bi binding and cell adherence, but not cell-mediated lysis and it cross-reacts with human CD11b.
Additional Information
Clone:
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M1/70
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Format:
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SAFIRE Purified
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Applications:
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FC, FA, IHC
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Reactivity:
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Human, Mouse
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Isotype:
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Rat IgG2b, kappa
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Cell Type: | NK and NKT Cells, Macrophage / Monocyte |
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Application: | FC, FA, IHC |
Clone: | M1/70 |
Preparation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Sanchez-Madrid, F., Simon, P., Thompson, S., & Springer, T. A. (1983). Mapping of antigenic and functional epitopes on the alpha-and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1.The Journal of experimental medicine, 158(2), 586-602. Ault, K. A., & Springer, T. A. (1981). Cross-reaction of a rat-anti-mouse phagocyte-specific monoclonal antibody (anti-Mac-1) with human monocytes and natural killer cells. The Journal of Immunology, 126(1), 359-364. Springer, T., Galfre, G., Secher, D. S., & Milstein, C. (1978). Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. European journal of immunology, 8(8), 539-551. |