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Anti-Human CD54 (ICAM-1) APC



Catalog Number : 06611-80

Description

The 15.2 antibody reacts with the 85-110 kDa intracellular adhesion molecule-1 (ICAM-1), a member of the Ig superfamily which acts as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1). ICAM-1 is also known CD 54 and is expressed on non-hematopoietic cells of vascular endothelial, thymic epithelial, fibroblasts lineages, and on hematopoietic cells like macrophages, mitogen-stimulated T-lymphoblasts, dendritic cells in tonsils, lymph nodes and Peyer’s patches, and germinal center B cells.

Inflammatory mediators (IL-1, TNF, IFN-γ) enhance the production of ICAM-1 on fibroblasts and endothelial cells within few hours. Thus, ICAM-1 seems to be the marker of inflammatory reactions.

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Human peripheral blood lymphocytes were stained with APC 15.2 with relevant isotype control in Red.
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Additional Information

Clone
15.2
Format:
APC
Applications
FC
Reactivity
Human
Isotype:
Mouse IgG1
Research Interest: Adaptive Immunity, Angiogenesis
Cell Type: B Cells, Monocytes and Macrophages, T Cells, Dendritic Cells
Protein Cross Reactivity: Pig
Preperation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Bhattacharya, A. L. O. K., Dorf, M. E., & Springer, T. A. (1981). A shared alloantigenic determinant on Ia antigens encoded by the IA and IE subregions: evidence for I region gene duplication. The Journal of Immunology127(6), 2488-2495.

Mendiratta, S. K., Singh, N., Bal, V., & Rath, S. (1996). Analysis of T-cell hybridomas with an unusual MHC class II-dependent ligand specificity.Immunology89(2), 238-244.

Unternaehrer, J. J., Chow, A., Pypaert, M., Inaba, K., & Mellman, I. (2007). The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface. Proceedings of the National Academy of Sciences,104(1), 234-239.


Availability: In stock

Size Price Qty
25 tests
$120.00
100 tests
$315.00
Additional 15.2 Formats
Cat.No. Format Starting From
06611-60PE $ 95.00
06611-20Purified $ 105.00
06611-25SAFIRE Purified $ 195.00
06611-50FITC $ 85.00
06611-80APC $ 120.00