GSK923295
description
Additional Information
Applications:
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FA
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Synonyms:
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GSK-923295
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Formulation:
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Crystalline solid
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Chemical Name:
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3-chloro-N-[(2S)-1-[[2-(dimethylamino)acetyl]amino]-3-[4-[8-[(1S)-1hydroxyethyl]imidazo[1,2-a]pyridin-2-yl]phenyl]propan-2-yl]-4-propan-2-yloxybenzamide
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Molecular Formula:
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C32H38ClN5O4 |
Molecular Weight: |
592.1
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CAS Number
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1088965-37-0
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Chung, V., Heath, E. I., Schelman, W. R., Johnson, B. M., Kirby, L. C., Lynch, K. M., ... & Holen, K. D. (2012). First-time-in-human study of GSK923295, a novel antimitotic inhibitor of centromere-associated protein E (CENP-E), in patients with refractory cancer. Cancer chemotherapy and pharmacology, 69(3), 733-741. Qian, X., McDonald, A., Zhou, H. J., Adams, N. D., Parrish, C. A., Duffy, K. J., ... & Jiang, H. (2010). Discovery of the first potent and selective inhibitor of centromere-associated protein E: GSK923295. ACS medicinal chemistry letters, 1(1), 30-34. Wacker, S. A., & Kapoor, T. M. (2010). Targeting a kinetochore-associated motor protein to kill cancer cells. Proceedings of the National Academy of Sciences, 107(13), 5699-5700. |